原著論文

【2017年】

1. Takako Takai-Igarashi1, Kengo Kinoshita, Masao Nagasaki, Soichi Ogishima, Naoki Nakamura, Sachiko Nagase, Satoshi Nagaie, Tomo Saito, Fuji Nagami, Naoko Minegishi, Yoichi Suzuki,Kichiya Suzuki, Hiroaki Hashizume, Shinichi Kuriyama, Atsushi Hozawa, Nobuo Yaegashi, Shigeo Kure, Gen Tamiya, Yoshio Kawaguchi, Hiroshi Tanaka, Masayuki Yamamoto
Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design.
BMC Medical Informatics and Decision Making, DOI 10.1186/s12911-017-0494-5, 2017

2. Iwata N, Ishikawa T, Okazaki S, Mogushi K, Baba H, Ishiguro M, Kobayashi H, Tanaka H, Kawano T, Sugihara K, Uetake H. Clinical Significance of Methylation and Reduced Expression of the Quaking Gene in Colorectal Cancer.
Anticancer Res, 37(2):489-498, 2017

3.Low SK, Takahashi A, Ebana Y, Ozaki K, Christophersen IE, Ellinor PT; AFGen Consortium., Ogishima S, Yamamoto M, Satoh M, Sasaki M, Yamaji T, Iwasaki M, Tsugane S, Tanaka K, Naito M, Wakai K, Tanaka H, Furukawa T, Kubo M, Ito K, Kamatani Y, Tanaka T.
Identification of six new genetic loci associated with atrial fibrillation in the Japanese population.
Nat Genet , 2017 Apr 17. doi: 10.1038/ng.3842

【2016年】

1. Mizuno S, Ogishima S, Nishigori H, Jamieson DG, Verspoor K, Tanaka H, Yaegashi N, Nakaya J.
The Pre-Eclampsia Ontology: A Disease Ontology Representing the Domain Knowledge Specific to Pre-Eclampsia.
PLoS One, 2016 Oct 27;11(10):e0162828. doi: 10.1371/journal.pone.0162828. eCollection 2016

2. Kuriyama S, Yaegashi N, Nagami F, Arai T, Kawaguchi Y, Osumi N, Sakaida M, Suzuki Y, Nakayama K, Hashizume H, Tamiya G, Kawame H, Suzuki K, Hozawa A, Nakaya N, Kikuya M, Metoki H, Tsuji I, Fuse N, Kiyomoto H, Sugawara J, Tsuboi A, Egawa S, Ito K, Chida K, Ishii T, Tomita H, Taki Y, Minegishi N, Ishii N, Yasuda J, Igarashi K, Shimizu R, Nagasaki M, Koshiba S, Kinoshita K, Ogishima S, Takai-Igarashi T, Tominaga T, Tanabe O, Ohuchi N, Shimosegawa T, Kure S, Tanaka H, Ito S, Hitomi J, Tanno K, Nakamura M, Ogasawara K, Kobayashi S, Sakata K, Satoh M, Shimizu A, Sasaki M, Endo R, Sobue K, Tohoku Medical Megabank Project Study Group T, Yamamoto M.
The Tohoku Medical Megabank Project: Design and Mission.
J Epidemiol, Sep 5;26(9):493-511, 2016

3. Katsuta E, Tanaka S, Mogushi K, Shimada S, Akiyama Y, Aihara A, Matsumura S, Mitsunori Y, Ban D, Ochiai T, Kudo A, Fukamachi H, Tanaka H, Nakayama K, Arii S, Tanabe M.
CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells.
International Journal of Oncology, 48(2):657-69, 2016

4. Kikuchi M, Ogishima S, Mizuno S, Miyashita A, Kuwano R, Nakaya J, Tanaka H.
Network-Based Analysis for Uncovering Mechanisms Underlying Alzheimer's Disease.
Methods Mol Biol, 1303:479-91. doi: 10.1007/978-1-4939-2627-5_29, 2016

5. Ogishima S, Mizuno S, Kikuchi M, Miyashita A, Kuwano R, Tanaka H, Nakaya J.
AlzPathway, an Updated Map of Curated Signaling Pathways: Towards Deciphering Alzheimer's Disease Pathogenesis.
Methods Mol Biol, 1303:423-32. doi: 10.1007/978-1-4939-2627-5_25, 2016

6. Masuda T., Ishikawa T., Mogushi K., Okazaki S., Ishiguro M., Iida S., Mizushima H., Tanaka H., Uetake H., Sugihara K.
Overexpression of the S100A2 protein as a prognostic marker for patients with stage II and III colorectal cancer.
International Journal of Oncology, 48(3):975-82, 2016

7. Baba H., Ishikawa T., Mogushi K., Ishiguro M., Uetake H., Tanaka H., Sugihara K.
Identification of SATB1 as a Specific Biomarker for Lymph Node Metastasis in Colorectal Cancer.
Anticancer Reseach, 36:4069-4076, 2016

8. Mizuno S., Ogishima S., Kitatani K., Kikuchi M., Tanaka H., Yaegashi N., Nakaya J.
Network analysis of a comprehensive knowledge repository reveals a dual role for ceramide in Alzheimer’s disease
Plos One, 11(2): e0148431, 2016

9. Watanabe K., Tanaka H., Kurihara Y.
A Progression and Retrogression Mathematical Model for the Motor Learning Process.
IEEE Transactions on Human-machine Systems, 46(1):159-164, 2016

10. Shimizu C., Mogushi K., Morioka MS., Yamamoto H., Tamura K., Fujiwara Y., Tanaka H.
Fc-Gamma receptor polymorphism and gene expression of peripheral blood mononuclear cells in patients with HER2-positive metastatic breast cancer receiving single-agent trastuzumab.
Breast Cancer, 23(4):624-32, 2016 (IF: 1.585)

【2015年】

1. Ogishima S, Takai T, Shimokawa K, Nagaie S, Tanaka H, Nakaya J.
Integrated Database And Knowledge Base For Genomic Prospective Cohort Study In Tohoku Medical Megabank Toward Personalized Prevention And Medicine.
Stud Health Technol Inform, 216:1057,2015

2. Takeuchi JS, Ren F, Yoshikawa R, Yamada E, Nakano Y, Kobayashi T, Matsuda K, Izumi T, Misawa N, Shintaku Y, Wetzel KS, Collman RG, Tanaka H, Hirsch VM, Koyanagi Y, Sato K.
Coevolutionary dynamics between tribe Cercopithecini tetherins and their lentiviruses.
Sci Rep, Nov 4;5:16021, 2015

3. Nagaie S, Ogishima S, Nakaya J, Tanaka H.
A method to associate all possible combinations of genetic and environmental factors using GxE landscape plot.
Bioinformation, Mar 31;11(3):161-4, 2015

4. Ogishima S, Tanaka H, Nakaya J.
Modularity in the evolution of yeast protein interaction network.
Bioinformation, Mar 31;11(3):127-30, 2015

5. Takahashi H., Ishikawa T., Ishiguro M., Okazaki S., Mogushi M., Kobayashi H., Iida S., Mizushima H., Tanaka H., Uetake H., Sugihara K.
Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer.
BMC cancer, doi: 10.1186/s12885-015-1783-y, 2015

6. Matsumae H., Ishiwata R., Minamoto T., Ishida N., Ogishima S., Tanaka H.
Detection of periodic patterns in microarray data reveals novel oscillating transcripts of biological rhythms in Ciona intestinalis.
AROB Journal, 20:347–352, 2015

7. Junko S., Takeuchi., Ren F., Yoshikawa R., Yamada E., Nakano Y., Kobayashi T., Matsuda K., Izumi T., Misawa N., Shintaku Y., Katherine S W., Ronald G.C., Tanaka H., Vanessa MH., Koyanagi Y., and Sato K.
Coevolutionary dynamics between tribe Cercopithecini tetherins and their 1 lentiviruses.
Scientific Reports, doi: 10.1038/srep16021, 2015

8. Tanaka H., Ogishima S.
Network biology approach to epithelial-mesenchymal transition in cancer metastasis: three stage theory.
Journal of Molecular Cell Biology, 7(3):253-66. 2015 (IF: 6.870)

9. Aikawa T., Mogushi K., Iijima-Tsutsui K., Ishikawa K., Sakurai M., Tanaka H., Mizusawa H., Watase K.
Loss of MyD88 alters neuroinflammatory response and attenuates early Purkinje cell loss in a spinocerebellar ataxia type 6 mouse model.
Human Molecular Genetics, 24(17):4780-91, 2015 (IF: 6.393)

10. Miura T., Ban D., Tanaka S., Mogushi K., Kudo A., Matsumura S., Mitsunori Y., Ochiai T., Tanaka H., Tanabe M.
Distinct clinicopathological phenotype of hepatocellular carcinoma with EOB-MRI hyperintensity: association with gene expression signature.
The American Journal of Surgery, 210(3):561-9, 2015

11. Hasegawa H., Sato M., Tanaka H.
Evaluation of an X-Ray Dose Profile Derived from an Optically Stimulated Luminescent Dosimeter during Computed Tomographic Fluoroscopy.
PLoS One,10(7):e0132154, 2015(IF: 3.234)

12. Hori-Tanaka Y., Yura K., Takai-Igarashi T., Tanaka H.
Structural classification of steroid-binding sites on proteins by coarse-grained atomic environment and its correlation with their biological function.
Steroids, 96, 81-88. 2015 (IF: 2.639)

13. Sawai H., Takai-Igarashi T., Tanaka H.
Identification of Collaborative Activities with Oxidative Phosphorylation in Bipolar Disorder.
Bioinformation, 11(4):207-16, 2015.

14. Suzuki A., Takai-Igarashi T., Nakaya J., Tanaka H.
Development of an Ontology for Periodontitis.
Journal of Biomedical Semantics, 6:30. 2015(IF: 2.262)

15. Arner E, Daub C.O, Vitting-Seerup K, Andersson R, Lilje B, Drablos F, Lennartsson A, Rönnerblad M, Hrydziuszsko O,Vitezic M, Arner P, Baillie K, Bodega B, Brombacher F, Davis M, Detmar M, Ehrlund A, Endoh M, Fagiolini M, Faulkner G, Ferrai C, Fisher M.E, Goldowitz D, Guler R, Ha T, Hara M, Herlyn M, Ikawa T, Kai C, Kawamoto H, Khachigian L, Klinken P, Kojima S, Koseki H, Krampitz S, Mejhert N, Morimoto M, Morris K.J, Mummery C, Nakachi Y, Ogishima S, Okada M, Okazaki Y, Orlando V, Passier R, Pombo A, Qin X, Roy S, Sato H, Saxena A, Sugiyama D, Swoboda R, Tanaka H, Winteringham L, Wolvetang E, Yanagi C, Yoneda M, Zabierowski S, Zhang P, Abugessaisa I, Diehl AD, Fukuda S, Furuno M, Harshbarger J, Hasegawa A, Hori F, IKato S, Ishizu Y, Ito M, Kondo N, Lizio M, Meehan T.F, Mungall CJ, Nishiyori H, Sahin S, Severin J, de Hoon M.J.L, Kawai J, Kasukawa T, Lassmann T, Suzuki H, Kawaji H, Summers K,Wells S, Hume D, Forrest A,Sandelin A, Carninci P,Hayashizaki Y.
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.
Science, 347,1010-13, 2015

16. Moriya Y., Uzawa N, Morita T., Mogushi K., Miyaguchi K., Takahashi K., Michikawa C., Sumino J., Tanaka H., Harada K.
The high-temperature requirement factor A3 (HtrA3) is associated with acquisition of the invasive phenotype in oral squamous cell carcinoma cells
Oral Oncology, 51:84-89, 2015 (IF: 3.607)

17. Eslami A., Miyaguchi K., Mogushi K., Watanabe H., Okada N., Shibuya H., Mizushima H., Miura M., Tanaka H.
PARVB overexpression increases cell migration capability and defines high risk for endophytic growth and metastasis in tongue squamous cell carcinoma.
British Journal of Cancer, 112(2):338-344, 2015 (IF: 4.817)

【2014年】

1. Hase T., Kikuchi K., Ghosh S., Kitano H., Tanaka H.
Identification of drug-target modules in the human protein–protein interaction network
Artificial Life and Robotics, 19 (4): 406-413, 2014

2. Nukaya S., Sugie M., Kurihara Y., Hiroyasu T., Watanabe K., Tanaka H.
A noninvasive　heartbeat, respiration, and body movement monitoring system for neonates.
Artificial Life and Robotics, 19(4):414-419, 2014

3. Kobayashi T., Takeuchi J.S., Ren F., Matsuda K., Sato K., Kimura Y., Misawa N., Yoshikawa R., Nakano Y., Yamada E., Tanaka H., Hirsch V.M., Koyanagi Y.
Characterization of red-capped mangabey tetherin: implication for the co-evolution of primates and their lentiviruses
Scientific Reports, 4: 5529, doi: 10.1038/srep055292014 (IF: 5.578)

4. Yoshikawa R., Takeuchi J.S., Yamada E., Nakano Y., Ren F., Tanaka H., Münk C., Harris R.S., Miyazawa T., Koyanagi Y., Sato K.
Vif determines the requirement for CBF-β in APOBEC3 degradation
Journal of General Virology, doi: 10.1099/jgv.0.000027, 2014 (IF: 3.183)

5. Katsuta E., Tanaka S., Mogushi K., Matsumura S., Ban D., Ochiai T., Irie T., Kudo A., Nakamura N., Tanaka H., Tanabe M., Arii S.
Age-related clinicopathologic and molecular features of patients receiving curative hepatectomy for hepatocellular carcinoma.
The American Journal of Surgery, 208(3):450-456, 2014 (IF: 2.406)

6. Watanabe K., Kurihara Y., Watanabe K., Azami T., Nukaya S., Tanaka H.
Bio-Signals Sensing by Novel Use of Bi-directional Microphones in a Mobile Phone for
Ubiquitous Healthcare Monitoring.
IEEE Transactions on Human-Machine Systems, 2014, 44(4):545-550, 2014（IF: 1.982）

7. Tsubota A., Mogushi K., Aizaki H., Miyaguchi K., Nagatsuma K., Matsudaira H., Kushida T., Furihata T., Tanaka H., Matsuura T.
Involvement of MAP3K8 and miR-17-5p in Poor Virologic Response to Interferon-Based Combination Therapy for Chronic Hepatitis C.
PLoS One, 9(5):e97078, 2014（IF: 4.092）

8. Kudo A., Mogushi K., Takayama T., Matsumura S., Ban D., Irie T., Ochiai T., Nakamura N., Tanaka H., Anzai N., Sakamoto M., TanakaS., Arii S.
Mitochondrial metabolism in the noncancerous liver determine the occurrence of hepatocellular carcinoma: a prospective study.
J Gastroenterol, 49(3):502-10, 2014　 (IF:4.160)

9. Andersson R, Gebhard C, Irene Miguel-Escalada, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Ntini E, Arner E, Valen E, Li K, Schwarzfischer L, Glatz D, Raithel J, Lilje B, Rapin N, Frederik Otzen Bagger, Jørgensen M, Peter Refsing Andersen, Bertin N, Owen Rackham, A. Maxwell Burroughs, J. Kenneth Baillie, Ishizu Y, ShimizuY, Furuhata E, Shiori Maeda, Yutaka Negishi, Christopher J. Mungall, Terrence F. Meehan, Lassmann T, Itoh M, Kawaji H, Kondo N, Kawai J, Lennartsson A, Carsten O. Daub, Heutink P, David A. Hume, Torben Heick Jensen, Suzuki H, Hayashizaki Y, Müller F, The FANTOM Consortium（Tanaka H. incl.）, Alistair R. R. Forrest, Carninci P, Rehli M, & Sandelin A.
An atlas of active enhancers across human cell type and tissues.
Nature, 507(7493):455-461, 2014（IF: 38.597）

10. Alistair R. R. Forrest, Hideya Kawaji, Michael Rehli, J. Kenneth Baillie, Michiel J. L. de Hoon, Vanja Haberle, Timo Lassmann, Ivan V. Kulakovskiy, Marina Lizio, Masayoshi Itoh, Robin Andersson, Christopher J. Mungall, Terrence F. Meehan, Sebastian Schmeier, Nicolas Bertin, Mette Jørgensen, Emmanuel Dimont, Erik Arner, Christian Schmidl, Ulf Schaefer, Yulia A. Medvedeva, Charles Plessy, Morana Vitezic, Jessica Severin, Colin A. Semple, Yuri Ishizu, Robert S. Young, Margherita Francescatto, Intikhab Alam, Davide Albanese, Gabriel M. Altschuler, Takahiro Arakawa, John A. C. Archer, Peter Arner, Magda Babina, Sarah Rennie, Piotr J. Balwierz, Anthony G. Beckhouse, Swati Pradhan-Bhatt, Judith A. Blake, Antje Blumenthal, Beatrice Bodega, Alessandro Bonetti, James Briggs, Frank Brombacher, A. Maxwell Burroughs, Andrea Califano, Carlo V. Cannistraci, Daniel Carbajo, Yun Chen, Marco Chierici, Yari Ciani, Hans C. Clevers, Emiliano Dalla, Carrie A. Davis, Michael Detmar, Alexander D. Diehl, Taeko Dohi, Finn Drabløs, Albert S. B. Edge, Matthias Edinger, Karl Ekwall, Mitsuhiro Endoh, Hideki Enomoto, Michela Fagiolini, Lynsey Fairbairn, Hai Fang, Mary C. Farach-Carson, Geoffrey J. Faulkner, Alexander V. Favorov, Malcolm E. Fisher, Martin C. Frith, Rie Fujita, Shiro Fukuda, Cesare Furlanello, Masaaki Furuno, Jun-ichi Furusawa, Teunis B. Geijtenbeek, Andrew P. Gibson, Thomas Gingeras, Daniel Goldowitz, Julian Gough, Sven Guhl, Reto Guler, Stefano Gustincich, Thomas J. Ha, Masahide Hamaguchi, Mitsuko Hara, Matthias Harbers, Jayson Harshbarger, Akira Hasegawa, Yuki Hasegawa, Takehiro Hashimoto, Meenhard Herlyn, Kelly J. Hitchens, Shannan J. Ho Sui, Oliver M. Hofmann, Ilka Hoof, Fumi Hori, Lukasz Huminiecki, Kei Iida, Tomokatsu Ikawa, Boris R. Jankovic, Hui Jia, Anagha Joshi, Giuseppe Jurman, Bogumil Kaczkowski, Chieko Kai, Kaoru Kaida, Ai Kaiho, Kazuhiro Kajiyama, Mutsumi Kanamori-Katayama, Artem S. Kasianov, Takeya Kasukawa, Shintaro Katayama, Sachi Kato, Shuji Kawaguchi, Hiroshi Kawamoto, Yuki I. Kawamura, Tsugumi Kawashima, Judith S. Kempfle, Tony J. Kenna, Juha Kere, Levon M. Khachigian, Toshio Kitamura, S. Peter Klinken, Alan J. Knox, Miki Kojima, Soichi Kojima, Naoto Kondo, Haruhiko Koseki, Shigeo Koyasu, Sarah Krampitz, Atsutaka Kubosaki, Andrew T. Kwon, Jeroen F. J. Laros, Weonju Lee, Andreas Lennartsson, Kang Li, Berit Lilje, Leonard Lipovich, Alan Mackay-sim, Ri-ichiroh Manabe, Jessica C. Mar, Benoit Marchand, Anthony Mathelier, Niklas Mejhert, Alison Meynert, Yosuke Mizuno, David A. de Lima Morais, Hiromasa Morikawa, Mitsuru Morimoto, Kazuyo Moro, Efthymios Motakis, Hozumi Motohashi, Christine L. Mummery, Mitsuyoshi Murata, Sayaka Nagao-Sato, Yutaka Nakachi, Fumio Nakahara, Toshiyuki Nakamura, Yukio Nakamura, Kenichi Nakazato, Erik van Nimwegen, Noriko Ninomiya, Hiromi Nishiyori, Shohei Noma, Tadasuke Nozaki, Soichi Ogishima, Naganari Ohkura, Hiroko Ohmiya, Hiroshi Ohno, Mitsuhiro Ohshima, Mariko Okada-Hatakeyama, Yasushi Okazaki, Valerio Orlando, Dmitry A. Ovchinnikov, Arnab Pain, Robert Passier, Margaret Patrikakis, Helena Persson, Silvano Piazza, James G. D. Prendergast, Owen J. L. Rackham, Jordan A. Ramilowski, Mamoon Rashid, Timothy Ravasi, Patrizia Rizzu, Marco Roncador, Sugata Roy, Morten B. Rye, Eri Saijyo, Antti Sajantila, Akiko Saka, Shimon Sakaguchi, Mizuho Sakai, Hiroki Sato, Hironori Satoh, Suzana Savvi, Alka Saxena, Claudio Schneider, Erik A. Schultes, Gundula G. Schulze-Tanzil, Anita Schwegmann, Thierry Sengstag, Guojun Sheng, Hisashi Shimoji, Yishai Shimoni, Jay W. Shin, Christophe Simon, Daisuke Sugiyama, Takaaki Sugiyama, Masanori Suzuki, Naoko Suzuki, Rolf K. Swoboda, Peter A. C. ’t Hoen, Michihira Tagami, Naoko Takahashi, Jun Takai, Hiroshi Tanaka, Hideki Tatsukawa, Zuotian Tatum, Mark Thompson, Hiroo Toyoda, Tetsuro Toyoda, Eivind Valen, Marc van de Wetering, Linda M. van den Berg, Roberto Verardo, Dipti Vijayan, Ilya E. Vorontsov, Wyeth W. Wasserman, Shoko Watanabe, Christine A. Wells, Louise N. Winteringham, Ernst Wolvetang, Emily J. Wood, Yoko Yamaguchi, Masayuki Yamamoto, Misako Yoneda, Yohei Yonekura, Shigehiro Yoshida, Susan E. Zabierowski, Peter G. Zhang, Xiaobei Zhao, Silvia Zucchelli, Kim M. Summers, Harukazu Suzuki, Carsten O. Daub, Jun Kawai, Peter Heutink, Winston Hide, Tom C. Freeman, Boris Lenhard, Vladimir B. Bajic, Martin S. Taylor, Vsevolod J. Makeev, Albin Sandelin, David A. Hume, Piero Carninci & Yoshihide Hayashizaki.
A promoter-level mammalian expression atlas.
Nature,507(7493):462-470, 2014（IF: 38.597）

【2013年】

1. Kikuchi M., Ogishima S., Miyamoto T., Miyashita A., Kuwano R., Nakaya R., Tanaka H. Identification of Unstable Network Modules Reveals Disease Modules Associated with the Progression of Alzheimer’s Disease.
PLoS ONE, 8(11): e76162. DOI: 10.1371/journal.pone.0076162, 2013（IF: 4.092）

2. Tanaka Y, Nogata H, Tanaka H.
Effect of Music upon Awakening from Nap.
Biomedical Soft Computing and Human Sciences, 18(2):29-37, 2013（IF: なし）

3. Tanaka K, Ishihara T, Sugizaki T, Kobayashi D, Yamashita Y, Tahara K, Yamakawa N, Iijima K, Mogushi K, Tanaka H, Sato K, Suzuki H, Mizushima T.
Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease.
Nature Communications, 4:2686, 2013（IF: 10.015）

4. Mogushi K, Tanaka H.
PathAct: a novel method for pathway analysis using gene expression profiles.
Bioinformation, 9(8): 394-400, 2013（IF: なし）

5. Ogishima S, Mizuno S, Kikuchi M, Miyashita A, Kuwano R, Tanaka H, Nakaya J.
A Map of Alzheimer's Disease-Signaling Pathways: A Hope for Drug Target Discovery.
Clinical Pharmacology & Therapeutics, 93(5):399-401, 2013 （IF:6.043）

6. Muramatsu S, Tanaka S, Mogushi K, Adikrisna R, Aihara A, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Nakayama K, Tanaka H, Yamaoka S, Arii S.
Visualization of stem cell features in human hepatocellular carcinoma enlightened in vivo significance of tumor-host interaction and clinical implication.
Hepatology, 58(1):218-28, 2013（IF:12.003）

7. Takahashi M, Obayashi M, Ishiguro T, Sato N, Niimi Y, Ozaki K, Mogushi K, Mahmut Y, Tanaka H, Tsuruta F, Dolmetsch R, Yamada M, Takahashi H, Kato T, Mori O, Eishi Y, Mizusawa H, Ishikawa K.
Cytoplasmic Location of alpha1A Voltage-Gated Calcium Channel C-Terminal Fragment (Cav2.1-CTF) Aggregate Is Sufficient to Cause Cell Death.
PLoS One,8(3):e50121, 2013（IF:4.092）

8. Rotkrua P, Shimada S, Mogushi K, Akiyama Y, Tanaka H, Yuasa Y.
Circulating microRNAs as biomarkers for early detection of diffuse-type gastric cancer using a mouse model.
British Journal of Cancer,108(4):932-40, 2013（IF:5.042）

9. Sato K., Tanaka S., Mitsunori Y., Mogushi K., Yasen M., Aihara A., Ban D., Ochiai T., Irie T., Kudo A., Nakamura N., Tanaka H., Arii S.
Contrast-enhanced intraoperative ultrasonography for vascular imaging of hepatocellular carcinoma; clinical and biological significance.
Hepatology, 57(4):1436-47, 2013（IF:12.003）

10. Mayinuer A., Yasen M., Mogushi K., Obulhasim G., Xieraili M., Aihara A., Tanaka S., Mizushima H., Tanaka H., Arii S.
Upregulation of Protein Tyrosine Phosphatase type IVA member 3 (PTP4A3/PRL-3) Associated with tumor differentiation and a poor prognosis in human hepatocellular carcinoma.
Annals of Surgical Oncology, 20:305-17, 2013（IF:4.166）

11. Sumino J., Uzawa N., Okada N., Miyaguchi K., Mogushi K., Takahashi KI., Sato H., Michikawa C., Nakata Y., Tanaka H., Amagasa T.
Gene expression changes in initiation and progression of oral squamous cell carcinomas revealed by laser microdissection and oligonucleotide microarray analysis.
International Journal of Cancer, 132(3):540-8, 2013（IF:5.444）

12. Kikuchi A., Ishikawa T., Mogushi K., Ishiguro M., Iida S., Mizushima H., Uetake H., Tanaka H., Sugihara K.
Identification of NUCKS1 as a colorectal cancer prognostic marker through integrated expression and copy number analysis.
International Journal of Cancer, 132(10):2295-302, 2013（IF:5.444）

13. Obulhasim G., Yasen M., Kajino K., Mogushi K., Tanaka S., Mizushima H., Tanaka H., Arii S., Hino O.
Up-regulation of dbpA mRNA in hepatocellular carcinoma associated with metabolic syndrome.
Hepatology International,7:215-25, 2013 (IF: 2.645)

14. Kudo A., Mogushi K., Takayama T., Matsumura S., Ban D., Irie T., Ochiai T., Nakamura N., Tanaka H., Anzai N., Sakamoto M., Tanaka S., Arii S.
Mitochondrial metabolism in the noncancerous liver determine the occurrence of hepatocellular carcinoma: a prospective study.
Journal of Gastroenterology, Doi: 10.1007/s00535-013-0791-4 2013 　(IF:4.160 )

【2012年】

1. Mizuno S., Iijima R., Ogishima S., Kikuchi M., Matsuoka Y., Ghosh S., Miyamoto T., Miyashita A., Kuwano R., Tanaka H.
AlzPathway: a comprehensive map of signaling pathways of Alzheimer's disease.
BMC Systems Biology,6:52, 2012（IF:3.148）

2. Katayama Y., Maeda M., Miyaguchi K., Nemoto S., Yasen M., Tanaka S., Mizushima H., Fukuoka Y., Arii S., Tanaka H.
Identification of pathogenesis-related microRNAs in hepatocellular carcinoma by expression profiling.
ONCOLOGY LETTERS, 4(4):817-23, 2012（IF:0.108）

3. Yae T., Tsuchihashi K., Ishimoto T., Motohara T., Yoshikawa M., Yoshida GJ., Wada T., Masuko T., Mogushi K., Tanaka H., Osawa T., Kanki Y., Minami T., Aburatani H., Ohmura M., Kubo A., Suematsu M., Takahashi K., Saya H., Nagano O.
Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.
Nature Communications,6(3):883, 2012（IF:10.015）

4. Khamas A., Ishikawa T., Mogushi K., Iida S., Ishiguro M., Tanaka H., Uetake H., Sugihara K.
Genome-wide screening for methylation-silenced genes in colorectal cancer.
International Journal of Oncology,41(2):490-6, 2012 (IF: 2.399)

5. Xieraili M., Yasen M., Mogushi K., Obulhasim G., Mayinuer A., Aihara A., Tanaka S., Mizushima H., Tanaka H., Arii S.
Villin 1 is a predictive factor for the recurrence of high serum alpha-fetoprotein-associated hepatocellular carcinoma after hepatectomy.
Cancer Science,103(8):1493-501, 2012　 (IF:3.325)

6. Khamas A., Ishikawa T., Shimokawa K., Mogushi K., Iida S., Ishiguro M., Mizushima H., Tanaka H., Uetake H., Sugihara K.
Screening for epigenetically masked genes in colorectal cancer Using 5-Aza-2'-deoxycytidine, microarray and gene expression profile.
Cancer Genomics & Proteomics,9(2):67-75, 2012 (IF:なし)

7. Suzuki S., Takai-Igarashi T., Fukuoka Y., Wall D.P., Tanaka H., Tonellato P.J.
Systems analysis of inflammatory bowel disease based on comprehensive gene information.
BMC Medical Genetics, Apr 5; 13:25, 2012　(IF:2.439)

8. Boeck M., Ogishima S., Tanaka H., Kramer S., Kaderali L.
Hub-centered gene network reconstruction using automatic relevance determination.
PLoS ONE,7(5):e35077, 2012（IF: 4.411）

9. Miyaguchi K., Uzawa N., Mogushi K., Takahashi K.I., Michikawa C., Nakata Y., Sumino J., Okada N., Mizushima H., Fukuoka Y., Tanaka H.
Loss of NKX3-1 as potential marker for an increased risk of occult lymph node metastasis and poor prognosis in oral squamous cell carcinoma.
International Journal of Oncology, 40(6):1907-14, 2012（IF: 2.571）

10. Shimada S., Mimata A., Sekine M., Mogushi K., Akiyama Y., Fukamachi H., Jonkers J., Tanaka H., Eishi Y., Yuasa Y.
Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer.
Gut,61(3):344-53, 2012（IF: 10.732）

11. Okazaki S., Ishikawa T., Iida S., Ishiguro M., Kobayashi H., Higuchi T., Enomoto M., Mogushi K., Mizushima H., Tanaka H., Uetake H., Sugihara K.
Clinical significance of UNC5B expression in colorectal cancer.
International Journal of Oncology,40(1):209-16, 2012 (IF: 2.571)

12. Yasen M., Obulhasim G., Kajino K., Mogushi K., Mizushima H., Tanaka S., Tanaka H., Hino O., Arii S.
DNA binding protein A expression and methylation status in hepatocellular carcinoma and the adjacent tissue.
International Journal of Oncology, 40(3):789-97, 2012 　(IF: 2.571)

13. Nukaya S., Shino T., Kurihara Y., Watanabe K., Tanaka H.
Noninvasive Bed Sensing of Human Biosignals via Piezoceramic Devices Sandwiched Between the Floor and Bed.
IEEE Sensors Journal, 12(3):431-38, 2012（IF: 1.473）

14. Sekiya I., Ojima M., Sizuki S., Yamaga M., Horie M., Koga H., Tsuji K., Miyaguchi K., Ogishima S., Tanaka H., Muneta T.
Human mesenchymal stem cells in synovial fluid increase in the knee with degenerated cartilage and osteoarthritis.
Journal of Orthopaedic Research,30(6):943-9, 2012 (IF: 2.976)

【2011年】

1. Takata H., Nagata H., Nogawa H., Tanaka H.
The current shortage and future surplus of doctors: a projection of the future growth of the Japanese medical workforce.
Human Resources for Health,9(1):14, 2011 (IF:なし)

2. Miyaguchi K., Fukuoka Y., Mizushima H., Yasen M., Nemoto S., Ishikawa T., Uetake H., Tanaka S., Sugihara K., Arii S., Tanaka H.
Genome-wide integrative analysis revealed a correlation between lengths of copy number segments and corresponding gene expression profile.
Bioinformation,7(6):280-4, 2011 (IF:なし)

3. Tanaka Y., Nakamura A., Morioka S M., Inoue S., Tamamori-Adachi M., Yamada K., Taketani K., Kawauchi J., Tanaka-Okamoto M., Miyoshi J., Tanaka H., Kitajima S.
Systems analysis of ATF3 in stress response and cancer reveals opposing effects on proapoptotic genes in p53 pathway.
Plos ONE,6(10):e26848, 2011（IF: 4.411）

4. Hatano A., Chiba H., Moesa HA., Taniguchi T., Nagaie S., Yamanegi K., Takai-Igarashi T., Tanaka H., Fujibuchi W.
CELLPEDIA: a repository for human cell information for cell studies and differentiation analyses.
Database,Doi:10.1093/database/bar046, 2011 (IF:なし)

5. Okamoto E., Miyamoto M., Hara K., Yoshida J., Muto M., Hirai A., Tatsumi H., Mizuno M., Nagata H., Yamakata D., Tanaka H.
Integrated care through disease-oriented clinical care pathways: experience from Japan`s regional health planning initiatives.
International Journal of Integrated Care,11(23):1-12, 2011 (IF:なし)

6. Tanaka S., Mogushi K., Yasen M., Ban D., Noguchi N., Irie T., Kudo A., Nakamura N., Tanaka H., Yamamoto M., Kokudo N., Takayama T., Kawasaki S., Sakamoto M., Arii S.
Oxidative stress pathways in non-cancerous liver tissue to predict hepatocellular carcinoma recurrence; a prospective multicenter study
Hepatology, 54(4):1273-81, 2011 (IF: 12.003)

7. Muto T., Taniguchi H., Kushima R., Tsuda H., Yonemori H., Chen C., Sugihara Y., Sakamoto K., Kobori Y., Palmer H., Nakamura Y., Tomonaga T., Tanaka H., Mizushima H., Fujita S., Kondo T.
Global expression study in colorectal cancer on proteins with alkaline isoele point by two-dimensional difference gel electrophoresis.
Journal of Proteomics, 74(6):858-73, 2011（IF: 5.074）

8. Yoshida I., Sugiura W., Shibata J., Ren F., Yang Z., Tanaka H.
Change of positive selection pressure on HIV-1 envelope gene inferred by early and recent samples.
PLoS ONE,6(4):e18630, 2011（IF: 4.411）

9. Ohashi K., Kurihara Y., Watanabe K., Ohno-Machado L., Tanaka H.
Feasibility Evaluation of Smart Stretcher to Improve Patient Safety during Transfers.
Methods of Information in Medicine, 49(6), 253-64, 2011 (IF: 1.472)

10. Johnson T.A., Niimura Y., Tanaka H., Nakamura Y., Tsunoda T.
hzAnalyzer: Detection, quantification, and visualization of contiguous homozygosity in high-density genotyping datasets.
Genome Biology, 12(3):R21, 2011（IF: 10.288）

11. Shibata J., Sugiura W., Ode H., Iwatani Y., Sato H., Tsang H., Matsuda M., Hasegawa N., Ren F., Tanaka H.
Within-host co-evolution of Gag P453L and protease D30N/N88D demonstrates virological advantage in a highly protease inhibitor-exposed HIV-1 case.
Antiviral Research,9(1): 33-41, 2011（IF: 4.439）

12. Naruo Y., Nagashima T., Ushikoshi-Nakayama R., Saeki Y., Nakakuki T., Naka T., Tanaka H., Tsai S.F., Okada-Hatakeyama, M.
Epidermal growth factor receptor mutation in combination with expression of MIG6 alters gefitinib sensitivity.
BMC Systems Biology,5(1):29, 2011（IF: 3.565）

13. Kishimoto T., Kondo J., Takai-Igarashi T., Tanaka H.
Accurate mass comparison coupled with two endopeptidases enables identification of protein termini
Proteomics,11:485-9, 2011（IF: 4.815）

14. Tsukamoto S., Ishikawa T., Iida S., Ishiguro M., Mogushi K., Mizushima H., Uetake H., Tanaka H., Sugihara K.
Clinical significance of osteoprotegerin expression in human colorectal cancer.
Clinical Cancer Research,17(8):2444-50, 2011（IF: 7.837）

15. Yoshitake K., Tanaka S., Mogushi K., Aihara A., Murakata A., Matsumura S., Mitsunori Y., Yasen M., Ban D., Noguchi N., Irie T., Kudo A., Nakamura N., Tanaka H., Arii S.
Importin-α1 as a novel prognostic target for hepatocellular carcinoma.
Annals of Surgical Oncology, 18(7):2093-103, 2011（IF: 4.166）

16. Murakata A., Tanka S., Mogushi K., Noguchi N., Irie T., Kudo A., Nakamura N., Tanaka H., Arii S.
Gene expression signature of the gross morphology in hepatocellular carcinoma.
Annals of Surgery,253(1):94-100, 2011（IF: 7.492）

17. Umemura H., Togawa A., Sogawa K., Satoh M., Mogushi K., Nishimura M., Matsushita K., Tanaka H., Takizawa H., Kodera Y., Nomura F.
Identification of a high molecular weight kininogen fragment as a marker for early gastric cancer by serum proteome analysis.
Journal of Gastroenterology, 46(5):577-85, 2011（IF: 4.160）

18. Kurihara Y., Watanabe K., Nakamura T., Tanaka H.
Unconstrained Estimation Method of Delta-Wave Percentage Included in EEG of Sleeping Subjects
IEEE Transactions on Biomedical Engineering, 58(3):607-15, 2011（IF: 1.790）

19. Tun K., Menghini M., D'Andrea L., Dhar P., Tanaka H., Giuliani A.
Why so few drug targets: a mathematical explanation.
Current Computer-Aided Drug Design,7(3):206-13, 2011（IF: 1.521）

20. Takai-igarash T., Akasaka R., Maruyama T., Inoue K., Suzuki K, Eguchi M., Yoshida M., Bando M, Takasaki M., Sakota M., Furukawa T., Maejima T., Konagaya A., Matsuura H., Suzumura T., Tanaka H.
On experiences of i2b2 (Informatics for Integrating Biology and the Bedside) database with Japanese Clinical Patients' data.
Bioinformation,6（2）:86-90, 2011（IF:なし）

【2010年】

1. Hase T., Niimura Y., Tanaka H.
Difference in gene duplicability may explain the difference in overall structure of protein-protein interaction networks among eukaryotes.
BMC evolutionary biology,10:358, 2010（IF: 4.294）

2. Shimokawa K., Mogushi K., Shoji S., Hiraishi A., Mizushima H., Tanaka H.
iCOD: an integrated clinical omics database based on the systems-pathology view of disease.
BMC Genomics, 11:S19, 2010（IF: 4.206）

3. Shimizu S., Iida S., Ishiguro M., Uetake H., Ishikawa T., Takagi Y., Kobayashi H., Higuchi T., Enomoto M., Mogushi K., Mizushima H., Tanaka H., Sugihara K.
Methylated BNIP3 gene in colorectal cancer prognosis.
Oncology Letters,1(5):865-72, 2010

4. Takano S., Sogawa K., Yoshitomi H., Shida T., Mogushi K., Kimura F., Shimizu H., Yoshidome H., Ohtsuka M., Kato A., Ishihara T., Tanaka H., Yokosuka O., Nomura F., Miyazaki M.
Increased circulating cell signalling phosphoproteins in sera are useful for the detection of pancreatic cancer.
British journal of Cancer, 103(2):223-31, 2010（IF: 5.042）

5. Nakahara I., Miyamoto M., Shibata T., Akashi-Tanaka S., Mogushi K., Oda K., Ueno M., Takakura N., Mizushima H., Tanaka H., Ohta T.
Up-regulation of PSF1 Promotes the Growth of Breast Cancer Cells.
Genes to Cells, 15(10):1015-24, 2010（IF: 2.952）

6. Ohashi K., Ota S., Ohno-Machado L., Tanaka H.
Smart medical environment at the point of care:Auto-tracking clinical interventions at the bed side using RFID technology.
Computers in Biology and Medicine,40(6):545-54, 2010（IF: 1.269）

7. Tanaka H.
Omics-based Medicine and Systems Pathology.
Methods of Information in Medicine,49:173-85, 2010（IF: 1.690）

8. Yoshida T., Kobayashi T., Itoda M., Muto T., Miyaguchi K., Mogushi K., Shoji S., Shimokawa K., Iida S., Uetake H., Ishikawa T., Sugihara K., Mizushima H., Tanaka H.
Clinical omics analysis of colorectal cancer incorporating copy number aberration and gene expression data.
Cancer Informatics,9:147-61, 2010

9. Matsuyama T., Ishikawa T., Mogushi K., Yoshida T., Iida S., Uetake H., Mizushima H., Tanaka H., Sugihara K.
MUC12 mRNA Expression is an independent marker of prognosis in stage II and stage III colorectal cancer.
International Journal of Cancer, 127:2292-9, 2010（IF: 5.444）

10. Tanaka S., Mogushi K., Yasen M., Noguchi N., Kubo A., Nakamura N., Ito K., Miki Y., Inazawa J., Tanaka H., Arii S.
Gene expression phenotypes for vascular invasiveness of hepatocellular carcinomas.
Surgery, 147:405-14, 2010（IF: 3.103）

11. Nakaya J., Kimura M., Hiroi K., Ido K., Yang W., Tanaka H.
Genomic sequence variation markup language (GSVML),
International Journal of Medical Informatics,79(2):130-42, 2010（IF: 3.126）

12. Watanabe K., Kurihara Y., Nakamura T., Tanaka H.
Design of a Low-Frequency Microphone for Mobile Phones and Its Application to Ubiquitous Medical and Healthcare Monitoring
IEEE Sensors Journal, 10(5):934-41, 2010（IF: 1.610）

13. Nakagawa M., Sakamoto N., Ueyama M., Mogushi K., Nagaie S., Itsui Y., Azuma S., Kakinuma S., Tanaka H., Enomoto N., Watanabe M.
Mutations in the interferon sensitivity determining region and virological response to combination therapy with Pegylated-interferon alpha 2b plus ribavirin in patients with chronic hepatitis C-1b infection.
Journal of Gastroenterology, 45:656-65, 2010（IF: 4.160）

14. Nishimura-Sakurai Y., Sakamoto N., Mogushi K., Nagaie S., Nakagawa M., Itsui Y., Sekine-Osajima Y., Tasaka-Fujita M., Onuki-Karakama Y., Suda G., Mishima K., Yamamoto M., Ueyama M., Funaoka Y., Watanabe T., Chen CH., Kakinuma S., Tsuchiya K., Tanaka H., Enomoto N., Watanabe M.
Comparison of HCV-associated gene expression and cell signaling pathways in cells without HCV replicon and in replicon-cured cell.
Journal of Gastroenterology,45(5):523-36, 2010（IF: 4.160）

15. Tsubota A., Mogushi K., Nariai K., Tanaka H., Tada N.
IQGAP1 and vimentin may be key regulator genes in naturally occurring hepatotumorigenesis induced by oxidative stress.
Carcinogenesis, 31(3):504-11, 2010（IF: 5.702）

16. Ohashi W., Tanaka H.
Benefits of pharmacogenomics in drug development - earlier launch of drugs and less adverse events
Journal of Medical Systems,34(4):701-7, 2010 　(IF: 0.674)

17. Kurihara Y., Watanabe K., Tanaka H.Sleep-States –Transition Model by Body Movement and Estimation of Sleep-Stage-Appearance Probabilities by Kalman Filter.
IEEE Transactions on Information Technology in Biomedicine, 14(6):1428-35, 2010（IF: 1.707）

【2009年】

1. Yoshimura K., Takeuchi K., Nagasaki K., Ogishima S., Tanaka H., Iwase T., Akiyama F., Kuroda Y., Miki Y.
Prognostic value of matrix Gla protein in breast cancer.
Molecular Medicine Reports,2:549-53, 2009（IF: 0.220）

2. Watanabe K., Kurihara Y., Tanaka H.
Ubiquitous Health Monitoring at Home-Sensing of Human Biosignals on Flooring, on Tatami Mat, in the Bathtub, and in the Lavatory.
IEEE Sensors Journal,9(12):1847-1855, 2009 （IF: 1.610）

3. Hasegawa N., Sugiura W., Shibata J., Matsuda M., Ren F., Tanaka H.
Inferring within-patient HIV-1 evolutionary dynamics under anti-HIV therapy using serial virus samples with vSPA.
BMC Bioinformatics, 10(1):360, 2009（IF: 3.781）

4. Hase T., Tanaka H., Suzuki Y., Nakagawa S., Kitano H.
Structure of protein interaction networks and their implications on drug design .
PLoS Computational Biology,5(10) e1000550, 2009（IF: 5.895）

5. Nagashima T., Ushikoshi-Nakayam R., Suenaga A., Ide K., Yumoto N., Naruo Y., Takahashi K., Saeki Y., Taiji M., Tanaka H., Tasai SF., Hatakeyama M.
Mutation of epidermal growth factor receptor is associated with MIG6 expression.
FEBS Journal,276:5239-5251, 2009（IF: 3.139）

6. Ishiwata RR., Morioka MS., Ogishima S., Tanaka H.
BioCichlid: central dogma-based 3D visualization system of time-course microarray data on a hierarchical biological network.
Bioinformatics,15 February, 25(4):543-544, 2009　(IF: 4.926)

7. Yasen M., Mizushima H., Mogushi K., Obulhasim G., Miyaguchi K., Inoue K., Makahara I., Ohta T., Aihara A., Tanaka S., Arii S., Tanaka H.
Expression of Aurora B and their Alternative Variant Forms in Hepatocellular　Carcinoma and the Adjacent Tissue.
Cancer Science,100(3):472-480, 2009 (IF: 3.771)

8. Ota MS., Kaneko Y., Kondo K., Ogishima S., Tanaka H., Eto K., Kondo T.
Combined in silico and in vitro analyses reveal role of Hes1 in taste cell
differentiation.
PLoS Genetics,5(4): e1000443, 2009　(IF: 9.532)

9. Tanaka S., Mogushi K., Yasen M., Noguchi N., Kubo A., Kurokawa T., Nakamura N., Inazawa J., Tanaka H., Arii S.
Surgical contribution to recurrence-free survival in patients with macrovascular invasionnegative hepatocellular carcinoma.
Journal of the American College of Surgeons,208(3):368-74, 2009 (IF: 4.549)

10. Ren F., Tanaka H., Yang Z.
A likelihood look at the supermatrix-supertree controversy.
Gene,441:119-125, 2009 (IF: 2.578)

11. Okamoto E., Fujii H., Tanaka H., Yamakata D., Nobutomo K., Nagata H.
Development of an IT infrastructure under Japan`s Health Care Reform 2008: a potential for regional health information networks.
Jpn J Med Inf,28(2):93-98, 2009

12. Suzuki A, Takai-igarashi T, Numabe Y, Tanaka H.
Development of a database and ontology for pathogenic pathways in periodontitis.
In Silico Biology,9:0020, 2009

【2008年】

1. Tun K., Rao RK., Samavedham L ., Tanaka H., Dhar P.K.
Rich can get poor: conversion of hub to non-hub proteins.
Systems and Synthetic Biology,2:75-82, 2008

2. Tanaka H.
Selected Studies from Current Medical Informatics Research in Japan.
Methods of Information in Medicine,47:511-512, 2008 (IF: 1.451)

3. Ohta T., Iijima K., Miyamoto M., Nakahara I., Tanaka H., Ohtsuji M., Suzuki T., Kobayashi A., Yokota J., Sakiyama T., Shibata T., Yamamoto M., Hirohashi S.
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.
Cancer Research,68:1303-9, 2008 (IF: 8.650)

4. Nakagawa S., Niimura Y., Gojobori T., Tanaka H*., Miura K.
Diversity of preferred nucleotide sequences around the translation initiation codon in eukaryote genomes. (*corresponding author)
Nucleic Acids Research,36:861-871, 2008 (IF: 8.273)

5. Tanaka S., Arii S., Yasen M., Mogushi K., Nguyen T., Zhao C., Imoto I., Eishi Y., Inazawa J., Miki Y., Tanaka H.
Aurora kinase B is a predictive factor for the aggressive recurrence of hepatocellular carcinoma after curative hepatectomy.
British Journal of Surgery, 95:611-619, 2008 (IF: 4.921)

6. Watanabe H., Mogushi K., Miura M., Yoshimura R.I., Kurabayashi T., Shibuya H., Tanaka H., Noda S., Iwakawa M., Imai T.
Prediction of lymphatic metastasis based on gene expression profile analysis after brachytherapy for early-stage oral tongue carcinoma.
Radiotherapy and Oncology,87:2237-42, 2008 (IF: 4.074)

7. Hase T., Niimura Y., Kaminuma T., Tanaka H.
Non-uniform survaival rate of heterodimerization links in the evolution of the yeast protein-protein interaction network.
PLoS ONE,3:e1667, 2008 (IF: 4.351)

8. Ohashi K., Sakamoto N., Watanabe M., Mizushima H., Tanaka H.
Development of a telediagnosis endoscopy system over secure internet.
Methods of Information in Medicine,47(2):157-166, 2008 (IF: 1.451)

9. Ohashi K., Kurihara Y., Watanabe K., Tanaka H.
Safe patient transfer system with monitoring of location and vital signs
Journal of Medical and Dental Sciences, 55:33-41, 2008

10. Ooe Y., Anamizu H., Tatsumi H., Tanaka H.
The Development of Network Infrastructure in Rural Areas and Problems in Applying IT to the Medical Field
Japan Hospitals, 27:65-69, 2008

11. Kurihara Y., Watanabe K., Kobayashi K., Tanaka H.
Observer Based on Body Movement Information in Sleeping and Estimation of Sleep Stage Appearances Probability
IEEJ Trans, 3:688-695, 2008

12. Kurihara Y., Watanabe K., Kikuchi T., Namba T., Tanaka H.
Potentialities of the Pneumatic Biosensing Bed as a Network Terminal for Ubiquitous Health Monitoring and Medical Care
IEEJ Trans,3:632-641, 2008

13. Endo A., Shibata T., Tanaka H.
Comparison of Seven Algorithms to Predict Breast Cancer Survival.
International Journal of Biomedical Soft Computing and Human Sciences,13:11-16, 2008

14. Okamoto E., Fujii H., Tanaka H., Yamakata D., Nobutomo K., Nagata H.
Development of an IT Infrastructure under Japan`s Health Care Reform 2008: A Potential for Regional Health Information Networks,
Japan Journal of Medical Informatics,28(2):93-98, 2008

15. Nakaya J., Tanaka H.
Clinical Omics Ontology and National Projects in Japan (toward Social Information Infrastucture),
Interdisciplinary Ontology Proceedings of the First Interdisciplinary Ontology Meeting, Keio University Press, 61-68, 2008

【2007年】

1. Tanaka H., Nakaya J.
Reseach and Education for Biomedical Informatics at Tokyo Medical and Dental University.
IMIA Yearbook of Medical Informatics, 46(1):157-62, 2007

2. Ogishima S., Tanaka H.
The missing link in the evolution of Hox clusters.
Gene, 387:21-30, 2007 (IF: 2.871)

3. Koeda M., Takahashi H., Yahata N., Matsuura M., Asai K., Okubo Y., Tanaka H.
Neural responses to human voice and hemisphere dominance for lexical-semantic processing--an fMRI study.
Methods of Information in Medicine,46:247-50, 2007　 (IF: 1.684)

4. Shima Y., Suwa A., Gomi Y., Nogawa H., Nagata H., Tanaka H.
Qualitative and quantitative assessment of video transmitted by DVTS (digital video transport system) in surgical telemedicine.
Journal of Telemedicine and Telecare2007, 13:148-53, 2007 (IF: 0.963)

5. Takata H., Tanaka H., Nogawa H., Nagata H., Gomi Y.
Implementation of Medical Diagnostic System Based on Epidemiological Data.
Journal of Korean Society of Medical Informatics, 13:181-185, 2007

6. Shibata J., Ren F., Nishizawa M., Fujino M., Iwatani Y., Matsuda M., Miura H., Tanaka H., Sugiura W.
Interference between gag non-cleavage site mutation P453L and HIV-1 protease non-drug resistance mutation E35D.
Antiviral Therapy,12:S143, 2007 (IF: 4.982)

7. Endo A., Shibata T., Tanaka H.
Predicting breast cancer survivability: comparison of five data mining techniques.
Journal of Korean Society of Medical Informatics, 13:177-180, 2007

【2006年】

1. Koeda M., Takahashi H., Yahata N., Matsuura M., Asai K., Okubo Y., Tanaka H.
Language processing and human voice perception in schizophrenia: A functional magnetic resonance imaging study.
Biological Psychiatry, 59:948-957, 2006 (IF: 9.247)

2. Ren F., Tsubota A., Hirokawa T., Kumada H., Yang Z., Tanaka H.
A unique amino acid substitution, T126I, in human genotype C of hepatitis B virus S gene and its possible influence on antigenic structural change.
Gene, 383:43-51, 2006 (IF: 2.871)

3. Koeda M., Takahashi H., Yahata N., Asai K., Okubo Y., Tanaka H.
A functional MRI Study: Cerebral laterality for lexical-semantic processing and human voice perception.
American Journal of Neuroradiology, 7:1472-1479, 2006 (IF: 2.525)

4. Gomi Y., Nogawa H., Tanaka H.
Toward secure distribution of electronic health records: Quantitative feasibility study on secure e-mail systems for sharing patient records.
Journal of Medical and Dental Sciences,52:229-236, 2006

5. Nakaya J., Shimizu T., Tanaka H.
e- protocol – A Translational Research (TR) protocol generator and monitor-,
International Journal of Computer Science and Network Security,6(7B):18-23, 2006

6. Nakaya J., Shimizu T., Tanaka H.
Condensed Cross-Clinical Knowledge,
International Journal of Computer Science and Network Security, 6(7A):6-11, 2006

【2005年】

1. Ren F., Tanaka H., Yang Z.
An empirical examination of the utility of codon-substitution models in phylogeny reconstruction.
Systematic Biology, 54:808-818, 2005 (IF: 12.169)

2. Hasegawa N., Sugiura W., Matsuda M., Mogushi K., Tanaka H., Ren F.
Inference of evolutionary forces driving HIV-1 drug-resistance acquisition under HAART using longitudinal HIV-1 protease gene samples.
Antiviral Therapy, 10:S114, 2005 (IF: 4.982)

3. Nakaya J., Shimizu T., Tanaka H., Asano S.
Current Translational Reseach in Australia and Translational Research Supporting Center (TRSC) in Japan.
Chem-Bio Informatics Journal,5(2):27-38, 2005

【2004年】

1. Shibata K., Ito T., Kitamura Y., Iwasaki N., Tanaka H., Kamatani N.
Simultaneous estimation of haplotype frequencies and quantitative trait parameters: applications to the test of association between phenotype and diplotype configuration.
Genetics, 168:525-539, 2004 (IF: 4.276)

2. Zhang Q., Ono N., Takahara Y., Tanaka H.
Replicated studentized-deviate detection applied to the identification of differentially expressed genes in TNF-alpha-stimulated cells.
Gene,324:89-96, 2004 (IF: 2.754)

3. Imanishi T., Itoh T., Suzuki Y., O'Donovan C., Fukuchi S., Koyanagi K.O., Barrero R.A., Tamura T., Yamaguchi-Kabata Y., Tanino M., Yura K., Miyazaki S., Ikeo K., Homma K., Kasprzyk A., Nishikawa T., Hirakawa M., Thierry-Mieg J., Thierry-Mieg D., Ashurst J., Jia L., Nakao M., Thomas M.A., Mulder N., Karavidopoulou Y., Jin L., Kim S., Yasuda T., Lenhard B., Eveno E., Suzuki Y., Yamasaki C., Takeda J.I., Gough C., Hilton P., Fujii Y., Sakai H., Tanaka S., Amid C., Bellgard M., Bonaldo M.M., Bono H., Bromberg S.K., Brookes A.J., Bruford E., Carninci P., Chelala C., Couillault C., Souza S.J., Debily M.A., Devignes M.D., Dubchak I., Endo T., Estreicher A., Eyras E., Fukami-Kobayashi K., R Gopinath G., Graudens E., Hahn Y., Han M., Han Z.G., Hanada K., Hanaoka H., Harada E., Hashimoto K., Hinz U., Hirai M., Hishiki T., Hopkinson I., Imbeaud S., Inoko H., Kanapin A., Kaneko Y., Kasukawa T., Kelso J., Kersey P., Kikuno R., Kimura K., Korn B., Kuryshev V., Makalowska I., Makino T., Mano S., Mariage-Samson R., Mashima J., Matsuda H., Mewes H.W., Minoshima S., Nagai K., Nagasaki H., Nagata N., Nigam R., Ogasawara O., Ohara O., Ohtsubo M., Okada N., Okido T., Oota S., Ota M., Ota T., Otsuki T., Piatier-Tonneau D., Poustka A., Ren S.X., Saitou N., Sakai K., Sakamoto S., Sakate R., Schupp I., Servant F., Sherry S., Shiba R., Shimizu N., Shimoyama M., Simpson A.J., Soares B., Steward C., Suwa M., Suzuki M., Takahashi A., Tamiya G., Tanaka H., Taylor T., Terwilliger J.D., Unneberg P., Veeramachaneni V., Watanabe S., Wilming L., Yasuda N., Yoo H.S., Stodolsky M., Makalowski W., Go M., Nakai K., Takagi T., Kanehisa M., Sakaki Y., Quackenbush J., Okazaki Y., Hayashizaki Y., Hide W., Chakraborty R., Nishikawa K., Sugawara H., Tateno Y., Chen Z., Oishi M., Tonellato P., Apweiler R., Okubo K., Wagner L., Wiemann S., Strausberg R.L., Isogai T., Auffray C., Nomura N., Gojobori T., Sugano S.
Integrative annotation of 21,037 human genes validated by full-length cDNA clones.
PLoS Biology, 2:856-875, 2004 (IF: 12.690)

4. Paum G., Suzuki Y., Tanaka H., Yokomori T.
On the power of membrane division in P systems.
Theoretical Computer Science,324:61-85, 2004 (IF: 0.764)

【2003年】

1. Endo T., Ogishima S., Tanaka H.
Standardized phylogenetic tree: a tool to discover functional evolution.
Journal of Molecular Evolution, 57:S174-181, 2003 (IF: 3.114)

2. Ren F., Ogishima S., Tanaka H.
Longitudinal phylogenetic tree of within-host viral evolution from noncontemporaneous samples: a distance-based sequential-linking method.
Gene,317:89-95, 2003 (IF: 2.778)

【2002年】

1. Endo T., Ogishima S., Tanaka H.
Tools to handle biological sequences and algnments for evolutionary studies.
Genome Informatics,13:543-544, 2002

2. Nagata H., Mizushima H., Tanaka H.
Concept and prototype of protein-ligand docking simulator with force feedback technology.
Bioinformatics,18:1-7, 2002 (IF: 4.615)

3. Suzuki Y., Takabayashi J., Tanaka H.
Investigation of tritrophic interactions in an ecosystem using abstract chemistry.
Artificial Life and Robotics, 6:129-132, 2002

4. Zhu J., Tanaka H., Kimura H., Kasanuki H.
Prognostic analysis based on the multiple components Weibull and its application to acute myocardial infarction.
Journal of Medical and Dental Sciences, 49:1-10, 2002

【2001年】

1. Tsubota A., Arase Y., Tanaka H., Ren F., Ikeda K., Kumada H.
Genotype may correlate with liver carcinogenesis and tumor characteristics in cirrhotic patients infected with hepatitis B virus subtype adw.
Journal of Medical Virology,65:257-265, 2001 (IF: 3.289)

2. Wang P., Abe K., Ojima T., Ohyashiki J.H., Sato H., Maruyama T., Nagata H., Tanaka H., and Yamamoto K.
3’-fluorine-substitution in 3’-fluorocarbocyclic oxetanocin A augment the drug’s inhibition of HHV-6B propagation in chronically infected cultures.
Microbiology and Immunology, 45:457-66, 2001 (IF: 1.154)

3. Ueda T., Hida S., Tanaka H., Kumagai Y., Kudou T. and Sugimoto H.
Telemedical support using real-time ultrasonography and endoscopy images.
Computer Method and Programs in Biomedicine,66:55-61, 2001

4. Ogishima S., Ren F. and Tanaka H.
Reconstruction and analysis of within-host longitudinal HIV-1 evolution by distance-based sequential-linking algorithm.
Chem-Bioinformatics Journal, 1:73-83, 2001

5. Paun G.., Suzuki Y. and Tanaka H.
P systems with energy accounting.
International Journal of Computer Mathematics,79: 173-186, 2001

【2000年】

1. Suzuki Y. and Tanaka H.
On a LISP implementation of a class of P Systems.
Romanian J. of Information Science,3:173-186, 2000

2. Suzuki Y. and Tanaka H.
Artificial proto-cell based on symbolic chemical system.
J. of Three Dimensional Images,Vol.14, 1144-149, 2000

3. Shibata T., Tsujimoto Y., Yoshimura K., Fukutomi T., Nanasawa T., Yamaguchi N. and Tanaka H.
Prognostic factor analysis of early death in stage II breast cancer.
Japan Journal of Medical Informatics,20:405-412, 2000

【1900年代】

1. Hamada Y., Miyashita E., Tanaka H.
Gamma-band oscillations in the barrel cortex precede rat’s exploratory whisking.
Neuroscience, 88:667-671, 1999 (IF: 3.924)

2. Suzuki Y. and Tanaka H.
Symbolic chemical system based on abstract rewriting system and its behavior pattern.
Artificial Life and Robotics,1: 211-219, 1997

3. Tsumoto S. and Tanaka H.
Incremental learning of probabilistic rules from clinical databases based on rough set theory.
Journal of the American Medical Informatics Association,4: 198-202, 1997 (IF: 2.164)

4. Tsumoto S. and Tanaka H.
A common framework of empirical learning methods based on rough sets and matroid theory.
Fundamentale Informaticae,27: 273-288, 1996

5. Tsumoto S. and Tanaka H.
Machine discovery of functional components of proteins from amino-acid sequences based on　rough sets and change of representation.
Journal of Intelligent Automation and Soft Computing, 2: 169-180, 1996

6. Tsumoto S., Ziarko W., Shan N. and Tanaka H.
Knowledge discovery in clinical databases based on variable precision rough set model.
Journal of the American Medical Informatics Association, 2:270-274, 1995 (IF: 2.164)

7. Tsumoto S. and Tanaka H.
PRIMEROSE: Probabilistic rule induction method based on rough sets and resampling methods.
Computational Intelligence,11:389-405, 1995 (IF: 0.643)

8. Ren F., Tanaka H. and Gojobori T.
Construction of molecular evolutionary phylogenetic trees from DNA sequences based on minimum complexity principle.
Computer Methods and Programs in Biomedicine,46:121-130, 1995 (IF: 0.887)

9. Tsumoto S. and Tanaka H.
Automated discovery of protein functional units from amino-acid sequences using rough-sets-based comparative analysis.
Genome Informatics, 6: 57-66, 1995

10. Tsumoto S. and Tanaka H.
Induction of medical expert system rules based on rough sets and resampling methods.
Journal of the American Medical Informatics Association, 1:1066-1070, 1994 (IF:　3.094)

11. Tsumoto S., Tanaka H., Tsumoto K., Kumagai I.
Comparative analysis of amino acid sequences based on rough sets and domain knowledge hierarchy.
Genome Informatics,5:59-69, 1994

12. Tsumoto S., Tanaka H., Amano H., Ohyama K. and Kuroda T.
COBRA: Integration of knowledge-bases with case-databases in the domain of congenital malformation.
International Journal of Cooperative Information Systems,4:387-403, 1993 (IF:0.951)

13. Kurata C., Tawarahara K., Sakata K., Fukumoto Y., Taguchi T., Kobayashi A., Yamazaki N. and Tanaka H.
Electrocardiographically and symptomatically silent myocardial ischemia during exercise testing.
Japanese Circulation Journal, 55:825-834, 1991

14. Ahlhelt H., Tanaka H., Nygards M.E., Furukawa T. and Wigertz O.
Computer simulation of cardiac pacing.
Pace-Pacing and Clinical Electrocardiology, 11:174-184, 1988 (IF:1.578)

15. Omichi M., Ito K., Nakao M., Nakano S., Miyazaki K., Miyake H., Tanaka H., Umezawa Y., Ogura T. and Sekita S.
The future of Japanese hospital: Projections by hospital directors and their implication.
Journal of the Japan Hospital Association, 7:1-13, 1988

16. Harumi K., Yamada K., Furukawa T., Musha T., Ohta T., Tanaka H., Kubota T., Teramachi, Y.
A proposal for the standardization of body surface potential mapping (BSPM) systems.
Japanese Heart Journal,28:35-142, 1987

17. Ahlhelt H., Tanaka H., Nygards M.E., Furukawa T., Wigertz O.
Computer simulation of cardiac arrhythmias.
Computer and Biomedical Research,20:305-323, 1987

172. Calderon A., Tanaka H., Furukawa T.
3-D mapping of body surface potential.
Medical Informatics,12:125-135, 1987

18. Tanaka H. and Furukawa T.
Estimation of location and size of myocardial injury site from body surface potential distribution using ECG inverse solution.
Japanese Heart Journal,27:235-244, 1986

19. Hara S., Tanaka H., Furukawa T.
Fluid therapy consultation system (FLUIDEX).
Automedica, 7:1-16, 1986

20. Yajima K., Kinoshita S., Tanaka H., Ihara T., Furukawa T.
Body surface potential mapping system equipped with a micro-processor for the dynamic observation of potential patterns.
Medical & Biological Engineering & Computing, 21: 83-90, 1983 (IF:0.943)

21. Furukawa T., Yajima K., Tanaka H., Akiba Y.
Application of the Weibull distribution to the analysis of the clinical course of disease.
Automedica, 3:151-163, 1980